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M9490394.TXT
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1994-09-19
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Document 0394
DOCN M9490394
TI Serodiagnosis of Penicillium marneffei infection.
DT 9411
AU Yuen KY; Wong SS; Tsang DN; Chau PY; Department of Microbiology, Queen
Mary Hospital, University of; Hong Kong.
SO Lancet. 1994 Aug 13;344(8920):444-5. Unique Identifier : AIDSLINE
MED/94335405
AB Diagnosis of Penicillium marneffei infection is often made late. We
evaluated an indirect immunofluorescent antibody test for P marneffei in
serum from 103 patients with persistent fever and from 78 normal
subjects. Germinating conidia (initial tissue-invasion phase) and
yeast-hyphae (tissue multiplication phase) forms were used as antigen.
All 8 documented P marneffei cases (8%) had an IgG titre of 160 or more;
the other 95 patients and all the healthy controls had an IgG titre of
40 or below. Blood culture was positive in only 1 case with HIV
infection. Biopsy and culture of tissues were necessary for confirmation
in the other 7 cases. The test could provide rapid presumptive diagnosis
and supplement conventional culture.
DE Antibodies, Fungal/*BLOOD Biopsy Case-Control Studies Cross Reactions
*Fluorescent Antibody Technique Human
Mycoses/BLOOD/*DIAGNOSIS/EPIDEMIOLOGY Penicillium/*CLASSIFICATION
Sensitivity and Specificity Serodiagnosis Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).